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ADC Therapeutics(ADCT)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Zynlonta	Loncastuximab tesirine	2021-04-23		Large b-cell lymphoma diffuse , B-cell lymphoma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

follicular lymphoma

,

large b-cell lymphoma diffuse

,

,

waldenstrom macroglobulinemia

,

b-cell lymphoma

,

,

non-hodgkin lymphoma

friedreich ataxia

,

amyotrophic lateral sclerosis

Calcium dobesilate

non-hodgkin lymphoma

,

follicular lymphoma

,

large b-cell lymphoma diffuse

,

prostatic neoplasms

,

lymphoid leukemia

,

squamous cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

interdigitating dendritic cell sarcoma

,

squamous cell neoplasms

,

adenosquamous carcinoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

philadelphia chromosome

,

myelodysplastic syndromes

,

graft vs host disease

,

gata2 deficiency

,

neoplasm metastasis

,

small cell carcinoma

,

neuroendocrine carcinoma

,

squamous cell carcinoma of head and neck

,

mouth neoplasms

,

,

,

,

,

pancreatic neoplasms

,

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

,

ovarian neoplasms

,

non-small-cell lung carcinoma

,

,

serous cystadenocarcinoma

,

b-cell lymphoma

,

myeloid leukemia acute

,

prostatic neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hematologic neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

cholangiocarcinoma

,

malignant mesothelioma

,

,

,

colorectal neoplasms

,

pancreatic ductal carcinoma

,

ovarian epithelial carcinoma

,

,

triple negative breast neoplasms

,

myeloid leukemia

,

head and neck neoplasms

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

breast neoplasms

,

multiple myeloma

,

plasma cell neoplasms

healthy volunteers/patients

,

,

bcr-abl positive chronic myelogenous leukemia

,

type 2 diabetes mellitus

,

glandular and epithelial neoplasms

,

,

gata2 deficiency

,

,

fallopian tube diseases

,

neurologic manifestations

,

,

bronchiolitis obliterans syndrome

,

interdigitating dendritic cell sarcoma

,

myeloproliferative disorders

,

neoplasms by histologic type

,

adenosquamous carcinoma

,

chronic hepatitis c

,

,

venous thromboembolism

,

thromboembolism

,

pharmacokinetics

,

central nervous system neoplasms

,

,

behcet syndrome

,

aids-related complex

,

pleural effusion

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

malignant pleural effusion

,

pleural diseases

,

pleural neoplasms

,

immunosuppression therapy

,

small cell lung carcinoma

,

transitional cell carcinoma

,

ovarian neoplasms

,

non-hodgkin lymphoma

,

triple negative breast neoplasms

,

squamous cell carcinoma

,

urologic neoplasms

,

,

biliary tract neoplasms

,

malignant mesothelioma

,

large b-cell lymphoma diffuse

,

,

uterine cervical neoplasms

,

neoplasms by site

,

castration-resistant prostatic neoplasms

,

endometrial neoplasms

,

,

squamous cell neoplasms

,

b-cell lymphoma

,

,

uveal neoplasms

,

,

hematologic neoplasms

,

t-cell lymphoma peripheral

,

t-cell lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

neuroendocrine tumors

,

gastrointestinal neoplasms

,

adenocarcinoma of lung

,

myeloid leukemia acute

,

cholangiocarcinoma

,

graft vs host disease

,

interstitial lung diseases

,

follicular lymphoma

,

merkel cell carcinoma

,

peritoneal neoplasms

,

spinocerebellar degenerations

,

,

graft rejection

,

psychology rejection

,

clear cell adenocarcinoma

,

,

,

,

rhabdomyosarcoma

,

,

autoimmune diseases

,

multiple sclerosis

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

burkitt lymphoma

,

female genital neoplasms

,

endometrioid carcinoma

,

,

,

urogenital neoplasms

,

organ transplantation

,

neuroendocrine carcinoma

,

urinary bladder diseases

,

microsatellite instability

,

basal cell carcinoma

,

basal cell neoplasms

,

diffuse scleroderma

,

laryngeal diseases

,

,

heart transplantation

,

,

male breast neoplasms

,

medulloblastoma

,

,

b-cell leukemia

,

tertiary lymphoid structures

,

oropharyngeal neoplasms

,

,

prostatic diseases

,

non-muscle invasive bladder neoplasms

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

diffuse intrinsic pontine glioma

,

diabetic neuropathies

,

nephrotic syndrome

,

focal segmental glomerulosclerosis

,

lipoid nephrosis

,

diabetic nephropathies

,

kidney diseases

,

common variable immunodeficiency

,

large-cell lymphoma anaplastic

,

,

phenylketonurias

,

bile duct neoplasms

,

serous cystadenocarcinoma

,

papillary thyroid cancer

,

,

salivary gland neoplasms

,

genetic therapy

,

smoldering multiple myeloma

,

uterine neoplasms

,

large cell carcinoma

,

endometrial stromal tumors

,

small cell carcinoma

,

penile neoplasms

,

adrenocortical carcinoma

,

digestive system diseases

,

,

,

,

,

invasive hydatidiform mole

,

,

,

,

bronchiolo-alveolar adenocarcinoma

,

drug-related side effects and adverse reactions

,

carcinoid tumor

,

hypersensitivity

,

thyroid neoplasms

,

precancerous conditions

,

bronchopulmonary dysplasia

,

tobacco smoking

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

meningeal carcinomatosis

,

systemic scleroderma

,

patient preference

,

,

oral leukoplakia

,

churg-strauss syndrome

,

microscopic polyangiitis

,

oligodendroglioma

,

myeloid leukemia

,

,

,

ankylosing spondylitis

,

,

inflammatory breast neoplasms

,

immunoglobulin g4-related disease

,

,

,

progressive multifocal leukoencephalopathy

,

gastrointestinal stromal tumors

,

male urogenital diseases

,

female urogenital diseases

,

female urogenital diseases and pregnancy complications

,

urogenital diseases

,

reactive arthritis

,

hereditary nonpolyposis colorectal neoplasms

,

,

aplastic anemia

,

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

neoplasm metastasis

,

squamous cell carcinoma of head and neck

,

prostatic neoplasms

,

head and neck neoplasms

,

breast neoplasms

,

pancreatic neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

urinary bladder neoplasms

,

,

brain neoplasms

,

stomach neoplasms

,

hodgkin disease

,

multiple myeloma

,

colonic neoplasms

,

,

,

rectal neoplasms

,

esophageal neoplasms

,

,

,

,

cutaneous malignant melanoma

,

pancreatic ductal carcinoma

,

fallopian tube neoplasms

,

systemic lupus erythematosus

,

myelodysplastic syndromes

,

plasma cell neoplasms

,

,

ovarian epithelial carcinoma

,

,

,

esophageal squamous cell carcinoma

,

ulcerative colitis

,

juvenile arthritis

,

psoriatic arthritis

,

sjogren's syndrome

,

,

,

lupus nephritis

,

giant cell arteritis

,

respiratory tract diseases

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

hyperlipidemias

,

polymyalgia rheumatica

,

vascular diseases

,

,

systemic vasculitis

,

disease progression

,

pathologic complete response

,

,

rheumatoid arthritis

,

renal cell carcinoma

,

,

,

kidney transplantation

,

acquired immunodeficiency syndrome

,

,

kidney neoplasms

,

delayed graft function

,

chronic kidney failure

,

coronary artery disease

,

,

hiv-associated lipodystrophy syndrome

,

epstein-barr virus infections

,

,

transplantation

,

mitochondrial diseases

,

,

,

parkinson disease

,

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

,

alzheimer disease

,

progressive supranuclear palsy

,

,

,

diabetes mellitus

follicular lymphoma

,

large b-cell lymphoma diffuse

healthy volunteers/patients

,

,

pheochromocytoma

,

neuroendocrine tumors

,

,

meningeal carcinomatosis

,

,

laryngeal neoplasms

,

pancreatic ductal carcinoma

,

,

head and neck neoplasms

,

squamous cell neoplasms

,

transitional cell carcinoma

,

malignant pleural effusion

,

fallopian tube neoplasms

,

small cell carcinoma

,

psychological inhibition

,

gastrointestinal neoplasms

,

dna repair-deficiency disorders

,

urinary bladder neoplasms

,

salivary gland neoplasms

,

,

,

radiation injuries

,

radiation effects

,

germ cell and embryonal neoplasms

,

peritoneal neoplasms

,

,

pleural effusion

,

,

residual neoplasm

,

breast neoplasms

,

type 2 diabetes mellitus

,

diabetes mellitus

,

neoplasm metastasis

,

,

,

prostatic neoplasms

,

,

,

small cell lung carcinoma

,

triple negative breast neoplasms

,

gastroesophageal reflux

,

,

,

,

,

rheumatoid arthritis

,

castration-resistant prostatic neoplasms

,

ovarian neoplasms

,

neoplasms by site

,

,

major depressive disorder

,

depressive disorder

,

,

peptic esophagitis

,

,

colorectal neoplasms

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

renal cell carcinoma

,

endometrial neoplasms

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

urologic neoplasms

,

stomach neoplasms

,

,

,

kidney diseases

,

,

cardiovascular diseases

,

pancreatic neoplasms

,

ovarian epithelial carcinoma

,

breast diseases

,

sickle cell anemia

,

brain neoplasms

,

,

,

opioid-induced constipation

,

,

hypercholesterolemia

,

biliary tract neoplasms

,

gallbladder neoplasms

,

disease progression

,

hereditary breast and ovarian cancer syndrome

,

,

chronic renal insufficiency

,

,

,

glucose metabolism disorders

,

metabolic diseases

,

endocrine system diseases

,

hypersensitivity

,

,

kidney neoplasms

,

,

zollinger-ellison syndrome

,

,

peptic ulcer hemorrhage

,

,

,

chronic obstructive pulmonary disease

,

obstructive lung diseases

,

,

anxiety disorders

,

,

venous thrombosis

,

pulmonary embolism

,

plexiform neurofibroma

,

neurofibromatosis 1

,

unknown primary neoplasms

,

respiratory insufficiency

,

myocardial infarction

,

coronary artery disease

,

bile duct neoplasms

,

cholangiocarcinoma

,

,

respiratory syncytial virus infections

,

uterine neoplasms

,

b-cell lymphoma

,

non-small-cell lung carcinoma

,

,

,

respiratory tract diseases

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

bronchial neoplasms

hodgkin disease

,

b-cell lymphoma

,

,

non-hodgkin lymphoma

,

,

b-cell lymphoma

,

Globulin, immune

non-small-cell lung carcinoma

,

,

prostatic neoplasms

,

pancreatic ductal carcinoma

,

malignant mesothelioma

,

ovarian epithelial carcinoma

,

,

medical sociology

,

,

,

,

b-cell chronic lymphocytic leukemia

,

hepatocellular carcinoma

,

lymphoid leukemia

,

squamous cell carcinoma of head and neck

,

colorectal neoplasms

,

breast neoplasms

,

large b-cell lymphoma diffuse

,

,

t-cell lymphoma peripheral

,

multiple myeloma

,

,

,

triple negative breast neoplasms

,

,

colonic neoplasms

,

neoplasm metastasis

,

b-cell lymphoma marginal zone

,

graft vs host disease

,

liver neoplasms

,

t-cell lymphoma

,

b-cell lymphoma

,

,

esophageal squamous cell carcinoma

,

,

animal mammary neoplasms

,

pancreatic neoplasms

,

,

spinocerebellar degenerations

,

bone marrow transplantation

,

esophageal neoplasms

,

myeloproliferative disorders

,

hematologic diseases

,

,

hodgkin disease

,

aplastic anemia

,

,

waldenstrom macroglobulinemia

,

myeloid leukemia chronic-phase

,

b-cell leukemia

,

bronchiolitis obliterans syndrome

,

squamous cell carcinoma

,

squamous cell neoplasms

,

non-hodgkin lymphoma

,

,

macular degeneration

,

follicular lymphoma

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

myelodysplastic syndromes

,

retinal diseases

,

vision disorders

,

,

,

intracranial hemorrhages

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

myeloid leukemia acute

,

,

antiphospholipid syndrome

,

thromboembolism

,

diabetes mellitus

,

appendiceal neoplasms

,

cystadenocarcinoma

,

neoplasms by histologic type

,

sezary syndrome

,

,

chromosome aberrations

,

female genital neoplasms

,

castration-resistant prostatic neoplasms

,

leukemia myeloid chronic atypical bcr-abl negative

,

,

,

cutaneous malignant melanoma

,

deltaretrovirus infections

,

htlv-i infections

,

composite lymphoma

,

pelvic neoplasms

,

abdominal neoplasms

,

urogenital neoplasms

,

gastrointestinal stromal tumors

,

squamous cell carcinoma of head and neck

,

,

invasive hydatidiform mole

,

plasmablastic lymphoma

,

,

adult t-cell leukemia-lymphoma

,

non-small-cell lung carcinoma

,

head and neck neoplasms

,

aids-related lymphoma

,

myeloid leukemia chronic-phase

,

thyroid neoplasms

,

intestinal neoplasms

,

primary effusion lymphoma

,

desmoplastic small round cell tumor

,

,

gastrointestinal neoplasms

,

t-cell lymphoma cutaneous

,

germ cell and embryonal neoplasms

,

,

thyroid diseases

,

cholangiocarcinoma

,

squamous cell carcinoma

,

ductal carcinoma

,

,

urologic neoplasms

,

primitive neuroectodermal tumors

,

primary myelofibrosis

,

uterine cervical neoplasms

,

adenoid cystic carcinoma

,

salivary gland neoplasms

,

breast carcinoma in situ

,

anaplastic thyroid carcinoma

,

thymus neoplasms

,

embryonal rhabdomyosarcoma

,

thrombocytopenia

,

healthy volunteers/patients

,

hypersensitivity

,

hairy cell leukemia

,

lymphomatoid granulomatosis

,

mycosis fungoides

,

,

,

myeloid leukemia accelerated phase

,

plasma cell leukemia

,

,

carcinoma in situ

,

endocrine gland neoplasms

,

bile duct neoplasms

,

esophageal squamous cell carcinoma

,

graft vs host disease

,

,

alveolar rhabdomyosarcoma

,

neurotoxicity syndromes

,

,

,

neuroendocrine tumors

,

nervous system neoplasms

,

,

intestinal diseases

,

intraocular lymphoma

,

castleman disease

,

,

phenylketonurias

,

b-cell leukemia

,

,

hereditary breast and ovarian cancer syndrome

,

adenomyoepithelioma

,

testicular neoplasms

,

,

neuroepithelial neoplasms

,

islet cell adenoma

,

,

pancreatic ductal carcinoma

,

,

,

chemotherapy-related cognitive impairment

,

immunoglobulin light-chain amyloidosis

,

,

renal insufficiency

,

,

human herpesvirus 8

,

cortical blindness

,

blastic plasmacytoid dendritic cell neoplasm

,

antineoplastic combined chemotherapy protocols

,

paranasal sinus neoplasms

,

febrile neutropenia

,

neoplasms by site

,

thromboembolism

,

,

,

gene rearrangement

,

prolymphocytic leukemia t-cell

,

,

,

cardiovascular abnormalities

,

prosthesis failure

,

,

essential thrombocythemia

,

polycythemia vera

,

diffuse intrinsic pontine glioma

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

experimental neoplasms

,

fibrous tissue neoplasms

,

optic nerve glioma

,

oligodendroglioma

,

disease progression

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

zollinger-ellison syndrome

,

post-traumatic stress disorders

,

,

,

,

adenoviridae infections

,

respiratory aspiration

,

mouth neoplasms

,

,

large cell carcinoma

,

vaginal neoplasms

,

vulvar neoplasms

,

epithelioid hemangioendothelioma

,

myxoid liposarcoma

,

vascular neoplasms

,

disorders of sex development

,

adipose tissue neoplasms

,

smooth muscle tumor

,

granular cell tumor

,

endometrial stromal sarcoma

,

minimally invasive surgical procedures

,

cystic fibrosis

,

vascular stiffness

,

triple negative breast neoplasms

,

ovarian neoplasms

,

neoplasm metastasis

,

,

,

stomach neoplasms

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

,

erythroblastic leukemia acute

,

,

ovarian epithelial carcinoma

,

megakaryoblastic leukemia acute

,

inflammatory breast neoplasms

,

,

prostatic neoplasms

,

male breast neoplasms

,

kidney neoplasms

,

endometrial neoplasms

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

fallopian tube neoplasms

,

esophageal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

congenital abnormalities

,

myeloproliferative disorders

,

transitional cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

myelomonocytic leukemia chronic

,

cardiovascular diseases

,

small cell lung carcinoma

,

,

colorectal neoplasms

,

,

pancreatic neoplasms

,

endometrioid carcinoma

,

hematologic neoplasms

,

,

b-cell lymphoma marginal zone

,

basophilic leukemia acute

,

refractory anemia with excess of blasts

,

,

,

,

eosinophilic leukemia acute

,

malignant fibrous histiocytoma

,

large-cell lymphoma immunoblastic

,

neoadjuvant therapy

,

,

myelodysplastic-myeloproliferative diseases

,

t-cell leukemia

,

acinar cell carcinoma

,

ureteral neoplasms

,

serous cystadenocarcinoma

,

renal cell carcinoma

,

peritoneal neoplasms

,

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

mucinous cystadenocarcinoma

,

ductal carcinoma breast

,

,

neurofibrosarcoma

,

malignant mesothelioma

,

mucinous adenocarcinoma

,

hemangiosarcoma

,

neuroectodermal tumors

,

synovial sarcoma

,

nerve sheath neoplasms

,

,

refractory anemia

,

urethral neoplasms

,

primitive neuroectodermal tumors peripheral

,

benign fibrous histiocytoma

,

ganglioneuroblastoma

,

brain neoplasms

,

myelomonocytic leukemia juvenile

,

acquired immunodeficiency syndrome

,

,

adrenocortical carcinoma

,

drug-related side effects and adverse reactions

,

eyelid neoplasms

,

residual neoplasm

,

hypereosinophilic syndrome

,

,

dermatofibrosarcoma

,

,

uterine neoplasms

,

clear cell adenocarcinoma

,

left ventricular dysfunction

,

,

central nervous system neoplasms

,

lobular carcinoma

,

,

,

clear cell sarcoma

,

interdigitating dendritic cell sarcoma

,

reactive arthritis

,

solitary fibrous tumors

,

myeloid sarcoma

,

pathologic complete response

,

gallbladder neoplasms

,

induction chemotherapy

,

chemotherapy-induced febrile neutropenia

,

,

connective and soft tissue neoplasms

,

epstein-barr virus infections

,

,

colonic neoplasms

,

adjuvant chemotherapy

,

,

hematologic diseases

,

ventricular dysfunction

,

hemangiopericytoma

,

pheochromocytoma

,

lymphadenopathy

,

alveolar soft part sarcoma

,

,

plasma cell granuloma

,

rectal neoplasms

,

adenosquamous carcinoma

,

lymphatic diseases

,

hemophagocytic lymphohistiocytosis

,

pulmonary blastoma

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

postoperative complications

,

perivascular epithelioid cell neoplasms

,

mesenchymal chondrosarcoma

,

choroid plexus neoplasms

,

retinal neoplasms

,

,

extravasation of diagnostic and therapeutic materials

,

progression-free survival

,

beckwith-wiedemann syndrome

,

adrenal cortex neoplasms

,

unknown primary neoplasms

,

respiratory insufficiency

,

connective tissue neoplasms

,

diastolic heart failure

,

,

positron-emission tomography

,

adolescent development

,

breast neoplasms

,

,

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

,

myeloid leukemia

,

b-cell lymphoma

,

hodgkin disease

,

lymphoid leukemia

,

,

liver neoplasms

,

myelodysplastic syndromes

,

,

hepatocellular carcinoma

,

multiple myeloma

,

burkitt lymphoma

,

follicular lymphoma

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

plasma cell neoplasms

,

,

urinary bladder neoplasms

,

mantle-cell lymphoma

,

,

,

biphenotypic leukemia acute

,

large-cell lymphoma anaplastic

,

rhabdomyosarcoma

,

cardiomyopathies

,

promyelocytic leukemia acute

,

philadelphia chromosome

,

immunoblastic lymphadenopathy

,

,

enteropathy-associated t-cell lymphoma

,

brain stem neoplasms

,

takotsubo cardiomyopathy

,

lymphoproliferative disorders

,

non-muscle invasive bladder neoplasms

,

breast diseases

,

second primary neoplasms

,

,

,

systolic heart failure

,

mediastinal neoplasms

,

,

male infertility

,

,

circulating neoplastic cells

,

,

alopecia areata

,

peripheral nervous system diseases

,

myocardial infarction

,

,

wounds and injuries

,

carcinoid tumor

,

,

erectile dysfunction

,

diabetic neuropathies

,

,

biliary tract neoplasms

,

,

ataxia telangiectasia

,

,

cerebellar ataxia

,

cardiac rehabilitation

,

chromosome disorders

,

gonadal disorders

,

,

cerebrovascular disorders

,

retroperitoneal neoplasms

,

endomyocardial fibrosis

,

pseudomyxoma peritonei

,

therapeutic chemoembolization

,

liver transplantation

,

malignant carcinoid syndrome

,

,

hyperlipidemias

,

diabetes mellitus

,

metabolic syndrome

,

hyperlipoproteinemias

,

intraductal carcinoma noninfiltrating

,

,

echocardiography

,

environmental biomarkers

,

myocardial contraction

,

physiological sexual dysfunction

,

,

,

cognitive dysfunction

,

peripheral arterial disease

,

peripheral vascular diseases

,

radiation injuries

,

eye abnormalities

,

,

gastrointestinal microbiome

,

coronary artery disease

,

microvascular angina

,

,

aortic valve stenosis

,

serotonin syndrome

,

,

cardiac imaging techniques

,

,

early detection of cancer

,

breast cancer lymphedema

,

respiratory insufficiency

,

atopic dermatitis

,

eczematous skin diseases

1

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